As a secreted protein Gal-8 is present in body fluids (e.g. synovial fluids of RA patients (25–60 nM) [7] or serum of breast (4.7–233.2 ng/ml) and colon (5.6–178.2 ng/ml) cancer patients [8]). Here, LGALS8 is linked to rheumatoid arthritis.