Linking ECM stiffness to YAP dysregulation, we note that several gene variants implicated in glaucoma such as caveolin 1 and 2 (CAV1,CAV2), lysyl oxidase–like 1 (LOXL1), and myocilin have separately been shown to modulate YAP regulation in a highly mechanosensitive manner, through actin-cytoskeleton–dependent, MST1/2 kinase, and Wnt signaling pathways, respectively.42 Here, YAP1 is linked to glaucoma.