PCSK9 and familial hypercholesterolemia: “Results using statin medications have been mixed in most trials ... In severe cases, such as familial hypercholesterolemia or treatment- resistant hypercholesterolemia, lipid apheresis may dramatically reduce Lp(a) ... Other medications that are in various stages of development include thyromimetics, cholesterol-ester-transfer protein (CETP inhibitors), anti-sense oligonucleopeptides, and proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors.” [30]