PCSK9 and familial Alzheimer disease: We induced atherosclerosis in a mild fAD model (J20-AD) to create a mixed comorbid model (J20-PCSK9-ATH) in which we report a significant increase in the number of hippocampal Aβ plaques, however, without any significant changes to evoked haemodynamic or neural responses compared to WT or J20-AD mice.