Together, these data indicate that whilst CSD has a profound effect on stimulation-evoked haemodynamic responses in all disease groups, time allows for recovery for WT, J20-AD and J20-PCSK9-MIX groups, but PCSK9-ATH; despite being recovered, are still affected due to genuine long-lasting neurovascular deficits. This evidence concerns the gene PCSK9 and Alzheimer disease.