The present study investigated neurovascular function in a novel experimental model of atherosclerosis (PCSK9-ATH) and for the first time, in a comorbid setting whereby atherosclerosis was experimentally induced in a well characterised model of AD; J20-hAPP, to create a mixed comorbid model (J20-PCSK9-MIX). The gene discussed is PCSK9; the disease is Alzheimer disease.