To further explore whether this mechanism could exert a regulatory function on DDP resistance in NSCLC cells, we firstly transfected si-XIAP into NSCLC cells to down-regulate the mRNA levels of XIAP (p < 0.05, Figure 6a), with si-XIAP-1 exhibiting better silencing efficiency was selected for a combined experiment with CAFs-oe-EVs. The gene discussed is XIAP; the disease is non-small cell lung carcinoma.