In this study, we determined to investigate the role of CAFs-EVs in DDP resistance in NSCLC cells, and consequently, we raised a hypothesis that lncRNA SNHG12 may be carried by CAFs-EVs into NSCLC cells and then affect DDP resistance in NSCLC cells via the via HuR/XIAP axis. The gene discussed is XIAP; the disease is non-small cell lung carcinoma.