Approximately 5%–10% of patients with CRC carry high-risk germline mutations that are associated with known hereditary CRC syndromes, including Lynch syndrome (also known as hereditary non-polyposis CRC), familial adenomatous polyposis (FAP), MUTYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartoma tumor syndrome, and serrated polyposis syndrome4–6. This evidence concerns the gene MUTYH and juvenile polyposis syndrome.