We tested the proteotoxic effects of mycolactone, alone and combined with BZ, in B‐cell acute lymphoblastic leukemia (B‐ALL) using mouse pro‐B‐cell lines generated by transformation of hematopoietic cells with the murine viral form of the Abelson oncogene (v‐abl). The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.