We tested the proteotoxic effects of mycolactone, alone and combined with BZ, in B‐cell acute lymphoblastic leukemia (B‐ALL) using mouse pro‐B‐cell lines generated by transformation of hematopoietic cells with the murine viral form of the Abelson oncogene (v‐abl). This evidence concerns the gene ABL1 and B-cell acute lymphoblastic leukemia.