While a direct comparison between isogenic t(4;14)‐positive and ‐negative cell lines would be required to conclude, this result suggests that gene deregulation caused by NSD2 overexpression and expansion of H3K36me2 in t(4;14) MM cells (Lhoumaud et al, 2019) may confer them with enhanced susceptibility to the pro‐death programs triggered by Sec61 blockade. This evidence concerns the gene NSD2 and Miyoshi myopathy.