In addition, we have demonstrated that ACE2 regulates mitochondrial function in pancreatic β-cells, inhibits hepatic insulin resistance, ameliorates hepatic steatosis, and improves glucose uptake in adipocytes (Cao et al., 2019; Cao et al., 2016; Cao et al., 2014; Liu et al., 2012a; Song et al., 2020; Yang et al., 2018). Here, ACE2 is linked to Hepatic steatosis.