Various mechanisms have been reported for the YAP1 to promote EMT including two recent studies indicating YAP1 and ZEB1 complex formation to activate ITGA3 transcription, which is marker and a driver of EMT,18 its high expression has recently been found to correlate with poor prognosis in NSCLC patients.29 The gene discussed is ITGA3; the disease is non-small cell lung carcinoma.