In addition, analysis of the PRAD TCGA data revealed that EIF4G1, a member of the EIF4F complex required for ER stress‐induced translation of ATF4, and ASNS, a canonical ATF4 target, were significantly enriched in tumours with high THEM6 expression (Fig 5H and Table EV3), thus underpinning the importance of THEM6 in the establishment of the ATF4‐mediated stress response. This evidence concerns the gene ATF4 and prostate adenocarcinoma.