In order to illustrate how such simulations can be used for strategic planning, we subsetted the simulated brain cancer population for IDH‐mutated tumors and performed information theory calculations to determine the utility of age, gender, site, IDH status, 1p19q status, and immunohistochemical detection of Olig2, GFAP, CD34, synaptophysin, p53, and ATRX (Figure 1E). The gene discussed is TP53; the disease is brain cancer.