Though ageing and the APOE gene represent the most well-known nonmodifiable risk factors for AD [20] and one-third of global AD cases globally are attributable to modifiable risk factors such as type 2 diabetes, hypertension, obesity, dyslipidemia, smoking, physical inactivity, smoking and depression [67], its pathogenesis is still not fully understood. This evidence concerns the gene APOE and Alzheimer disease.