In leiomyoma smooth muscle cells, gain-of function of miR-200c-3p repressed nuclear factor κB (NF-κB) pathway by targeting inhibitor of nuclear factor κB kinase subunit B (IKBKB), thereby reducing the ability of NF-κB p65 binding to IL-8 promoter (Chuang and Khorram 2014). The gene discussed is NFKB1; the disease is leiomyoma.