To address this issue, we compared the severity of colitis in Cdcs1+/+ (C57BL/6) mice lacking either Il10ra alone or both Il10ra and Ccr2. Consistent with our previously reported results, we observed that Cdcs1+/+Il10ra−/− mice exhibit robust spontaneous colitis by 4–5 weeks of age. The gene discussed is CCR2; the disease is colitis.