IL12B and colitis: Consistent with reduced histologic signs of colitis, we observed decreased expression of genes associated with pathogenesis of colitis, including Il12b, Infg, and the IFNg regulated gene Cxcl9, within total RNA isolated from the colon of Cdcs1+/+Il10ra−/−Ccr2−/− mice compared to expression observed within the colon of Cdcs1+/+Il10ra−/− mice (Fig. 1C).