ADORA2A and neoplasm: The combination of adoptive transfer of CL4 CTL with both ZM 241385 and anti-TIM3 mAb resulted in a marked reduction in tumor growth relative to mice given either CL4 T-cells alone or CL4 CTL plus ZM 241385 (Fig. 3c) suggesting that TIM3 enhances suppression of anti-RencaHA tumor immunity by A2AR already in this early phase of tumor growth.