Among the top 10 (affecting more than 13 out of 39 OS patients in this study) recurrently affected non-cancer genes, germline TE insertions of P2RX1 affected 21/39 OS patients and was recently shown to be associated with the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma liver metastases61. The gene discussed is P2RX1; the disease is cancer.