The top 10 recurrently affected non-cancer genes include P2RX1, PGM5P2, TXNRD2, LINC02270, PRH1, KLHL3, LOC105375989, LOC101928092, LOC105379418, and C13orf46 as shown in Fig. 4b, where each of these genes was affected in at least 13 out of 39 OS patients. The gene discussed is PRH1; the disease is cancer.