In addition, other cancer-related TFs were also found in our enrichment analysis, including ALX3 (in neuroblastoma)49, HOXA6 (in clear renal cell carcinoma)50, HOXC-8, FOXO1 (in breast cancer)51,52, PARP (in neuroblastoma, endometrial cancer, breast cancer, and malignant lymphoma)53–56, IPF1 (in pancreatic neuroendocrine neoplasms)57, and HOXB2 (in glioma)58. The gene discussed is ALX3; the disease is central nervous system cancer.