In addition, other cancer-related TFs were also found in our enrichment analysis, including ALX3 (in neuroblastoma)49, HOXA6 (in clear renal cell carcinoma)50, HOXC-8, FOXO1 (in breast cancer)51,52, PARP (in neuroblastoma, endometrial cancer, breast cancer, and malignant lymphoma)53–56, IPF1 (in pancreatic neuroendocrine neoplasms)57, and HOXB2 (in glioma)58. Here, PDX1 is linked to pancreatic neuroendocrine neoplasm.