The top 10 frequently affected cancer-associated genes are HIRA (OG), CSMD1 (TS), CDH13 (TS), PRRX1 (OG), FHIT (TS), MGAM (OG), TBL1XR1 (OG), RHOA (OG), FGF14 (TS), and CNTNAP2 (TS). The gene discussed is HIRA; the disease is cancer.