Similarly, out of 14 genes involved in DNA mismatch repair, 10 (i.e., RFC5, RFC4, RFC3, RFC1, PCNA, MSH6, MSH3, MSH2, LIG1, and EXO1) show significantly higher expression levels in OS tumor samples than normal controls (see Supplementary Fig. S1e). This evidence concerns the gene MSH3 and neoplasm.