RASSF1A hypermethylation was present in four IC-IPMN dissected regions—two in BD-IPMN cases, one in a MD-IPMN case, and one in a mixed IPMN case, in which no hypermethylation existed in comparable A-IPMN dissected regions. This evidence concerns the gene RASSF1 and pancreatic intraductal papillary-mucinous neoplasm.