RASSF1 and neoplasm: Additionally, methylation of cyclin-dependent kinase inhibitor 2A (CDKN2A), a tumor suppressor gene that encodes P16 (or P16INK4a) and P14arf14, long interspersed nuclear element-1 (LINE-1) retrotransposition, a major hallmark of cancer accompanied by global chromosomal instability, genomic instability, and genetic heterogeneity15, and Ras association domain family member 1A (RASSF1A), a tumor-suppressor gene frequently inactivated in various human cancers16,17 has been studied in pancreatic tumors14,18,19.