Davila, M. L analysed the correlations among 39 cytokines, the tumor burden prior to treatment and sCRS and found that the increased levels of 7 cytokines (interferon (IFN)-γ, interleukin (IL)-5, IL-6, IL-10, FIt-3L, granulocyte macrophage-colony stimulating factor (GM-CSF) and fractalkine) were related to the pretreatment tumor burden and to sCRS. The gene discussed is CX3CL1; the disease is neoplasm.