Recently, Xie et al. used DE genes in the TCGA and GEO datasets to construct a weighted gene co-expression network, and found that 6 gene features (RRAGB, RSPH9, RPS6KL1, RXFP1, RRM2, and RTL1) can be used for prognostic stratification of lung adenocarcinoma (the area under ROC curve (AUC) was 0.776 in predicting the 10-year survival of NSCLC patients)15. This evidence concerns the gene RRM2 and non-small cell lung carcinoma.