In fact, some of these proteins act by binding DNA and/or RNA [TAR DNA binding protein-43 (TDP-43), fused in sarcoma/translocated in liposarcoma (FUS), matrin-33–5]; some are enzymes [Cu/Zn superoxide dismutase 1 (SOD1), and valosin-containing protein (VCP)6,7]; others are implicated in protein degradation (p62/sequestosome-1)8, contribute to the formation of cytoskeleton (profilin-1)9 or regulate intracellular trafficking pathways [chromosome 9 open reading frame 72 (C9orf72)]10. The gene discussed is C9orf72; the disease is sarcoma.