Previously, others have studied the schweinfurthin family of compounds via genetic alterations using multivariate modeling of the GDSC (Genomics of Drug Sensitivity in Cancer) panel29, where they identified PLEKHO1, a negative regulator of PI3K/AKT signaling, as well as THEM4 and OSBP genes, as potential determinants of schweinfurthin response. This evidence concerns the gene THEM4 and cancer.