Interestingly, this data was confirmed not only in tumor bearing GPR120ΔIEC animals versus WT, as shown by qRT-PCR (Fig. 5f), and immunohistochemical analysis on colon sections from AOM/DSS-treated mice (Fig. 5g,h), but also on Caco-2 and LoVo cells, upon GPR120 silencing (Fig. 5i), suggesting that GPR120 may directly affect CRC cell proliferation through β-catenin signaling. This evidence concerns the gene FFAR4 and infectious otitis media.