Importantly, critical proteins implicated in neurodegeneration processes, including the ubiquitin-protein ligase A (UBE2A), which catalyzes the proteolytic clearing of toxic amyloid peptides in AD, and alpha-synuclein (SNCA), which accumulates in PD/AD, are known targets of miR-750,51. The gene discussed is SNCA; the disease is Parkinson disease.