A more modern classification based on molecular pathology includes categories such as alpha-synucleinopathies, either neuronal (PD, PDD, DLB) or oligodendroglial (MSA), tauopathies (also called FTLD-tau; PSP, CBD, argyrophilic grain disease, AGD, primary age-related tauopathy, PART, and globular glial tauopathy, GGT), FTLD with inclusions of proteins TDP-43 (FTLD-TDP), FUS (FTLD-FUS), or other with immunoreactivity for components of the ubiquitin-proteasome system (FTLD-UPS), and AD. The gene discussed is HMBS; the disease is argyrophilic grain disease.