PTEN loss in the murine prostatic epithelial in the PB-Cre+PtenloxP/loxP (Pten-null) mouse model mimics both molecular and pathological features associated with human prostate cancers, including upregulated PI3K pathway, invasive adenocarcinoma, as well as resistant to ADT15–17. This evidence concerns the gene PTEN and prostate carcinoma.