We then tested the long-term effects of 75 mg/Kg daily (BAY-D) and 180 mg/Kg intermittent (BAY-I) dosing schedules on 10 week-old castrated Pten-null prostate cancer mice when prostate developed high grade PIN/adenocarcinoma phenotypes15,36 (Fig. 2A). This evidence concerns the gene PTEN and prostate intraepithelial neoplasia.