To profile behavioral alterations in our new DS model and assess their eventual recovery following Nav1.1 protein re-expression, we subjected Scn1a+/+, Scn1aStop/+ -Ctrl, and Scn1aStop/+-Cre male mice at 3–4 months of age to a comprehensive battery of tests (Supplementary Fig. 5a, b). This evidence concerns the gene CTRL and Dravet syndrome.