In fact, quantification of the total Iba1+ microglial cells and Cd68 + /Iba1 + cells in the DG of the hippocampus of 8 week-old mice did not highlight any significant change between control and DS mouse brain, confirming that microglia is not characterized by an inflammatory state in our DS model (Supplementary Fig. 12b, c, d). Here, AIF1 is linked to Dravet syndrome.