PRDM16 and metastatic malignant neoplasm in the lymph nodes: We found some loss regions (Supplementary Data 4, CNV focal peak gene annotation) that contain a set of cancer-related genes, such as PCM1, PRDM16, and STK11. These genes displayed a copy-number loss in the CNV high group and may play a key role in the development of lymph node metastasis of IMPC.