Finally, highly reminiscent of the observations in BXD mice and thereby suggesting functional conservation of Grhl1/GRHL1 in mammals, we found that human skeletal muscle GRHL1 expression, in the GTEx cohort40, positively correlates with increased age at death and, in the FUSION tissue biopsy study dataset41,42, negatively with fasting blood glucose levels, including in individuals with impaired glucose tolerance or type 2 diabetes. This evidence concerns the gene GRHL1 and type 2 diabetes mellitus.