Substantial numbers of genes were identified in the astrocyte translatome of MAPTP301S and APP/PS1 astrocytes that were induced by both types of pathology, and this set is also enriched (around 30-fold) in a recently curated ‘chronic neurodegeneration’ signature derived from a meta-analysis of astrocyte transcriptomic data from ALS, Tau and Aß models54. Here, PSEN1 is linked to amyotrophic lateral sclerosis.