PSEN1 and Alzheimer disease: We performed enrichment analysis on those genes with 1:1 orthologs in mouse, expressed >10 FPKM (a higher than normal threshold since highly expressed genes are more likely to be detected in single-cell RNA-seq), and observed that genes upregulated in the translatome of both MAPTP301S and APP/PS1 astrocytes were enriched in genes induced in human AD astrocytes and moreover, the core set of genes induced by both Tau and Aß pathology was also enriched (Fig. 3C, left).