APP and tauopathy: As with the tauopathy model, we then then assessed the perturbation of these genes in a GFAP-Nrf2 background in the hippocampus and cortex (GFAP-Nrf2 vs. APP/PS1_X_GFAP-Nrf2, Fig. 9B, Supplementary Fig. 9B), and found that astrocytic Nrf2 overexpression substantially rescued this global transcriptomic perturbation driven by Aß pathology.