CAD and COVID-19: Here we report crystal structures of one public and one private TCR (YLQ7 and RLQ3, respectively) from COVID-19 CPs in complex with HLA-A*02:01 and two S protein epitopes, corresponding to residues 269–277 (YLQPRTFLL; designated YLQ) and 1000–1008 (RLQSLQTYV; designated RLQ), that were found to elicit almost universal CD8+ T cell responses in HLA-A2*02:01+ CPs but not in healthy donors26.