MYC and neoplasm: For instance, the level of enrichment in the KRAS targets signature presents extreme levels in the MVP niche, and is probably responsible for raising global levels of this signature in the whole tissues (Supplementary Fig. 34a); on the other hand, enrichment in the MYC targets signature is lowest in the non-tumour compartments LE and MVP, probably dampening the observed signal in bulk tissue taken near the infiltrating edge (Supplementary Fig. 34b).