We found that STING knockdown increased ZIKV infection to the same level in both luciferase and TMEM120A groups (Fig. 4a, b), indicating STING knockdown is epistatic to the antiviral phenotype of TMEM120A overproduction without affecting TMEM120A mRNA levels (Supplementary Fig. 9d, e). This evidence concerns the gene STING1 and Zika virus infectious disease.