Moreover, TMEM120A overexpression protected STING protein from being cleaved by NS2B3 protease without affecting STING mRNA level in HEK293T cells overexpressing STING (Supplementary Fig. 16b, c), suggesting that the association between TMEM120A and STING may at least partially contribute to the stabilization of STING level during ZIKV infection. Here, TMEM120A is linked to Zika virus infectious disease.