Since ZIKV preferentially infects neural stem/progenitor cells and immature neurons and causes microcephaly and other brain abnormalities in infants infected in utero15, we also confirmed the effect of IFNA2/IL27/TEPP on ZIKV infection in a glioma cell line U87MG (Supplementary Fig. 1). Here, SPMIP8 is linked to Zika virus infectious disease.