Both groups of mice developed a comparable degree of cardiac hypertrophy in response to TAC, as shown by similarly enhanced HW/TL ratio, embryonic gene expression (decrease in Myh6 and Atp2a2, increase in Myh7 and Acta1 mRNA) and cardiomyocyte size (Fig. 3e, Supplementary Fig. 3a–f). This evidence concerns the gene ATP2A2 and cardiac hypertrophy.