Consistently, the levels of p-β-catenin were decreased and the levels of β-catenin were increased in the lung homogenates derived from the BLM-induced mice compared to control mice (Fig. 6g), and loss of Acp5 largely reversed changes in the levels of β-catenin and p-β-catenin induced by BLM (Fig. 6g). Here, ACP5 is linked to Bloom syndrome.