To evaluate this, we performed EZH2 depletion in representative MYC(N)-driven small cell carcinoma NCI-H526 and NCI-H82 cells as well as MYC-driven Burkitt’s lymphoma Daudi cells, which are characterized by MYC(N) overexpression due to chromosome amplification or translocation. Here, EZH2 is linked to Burkitt lymphoma.