Yet, administration of the same dose of GSK126 caused MYC depletion and tumor growth inhibition in NCI-H82 xenografts (Fig. 7e and Supplementary Fig. 7e, f), indicating that GSK126 at these doses may disrupt EZH2-MYC interaction and induce MYC degradation in vivo. The gene discussed is EZH2; the disease is neoplasm.