To determine whether reduced tumor growth observed in GPR182−/− mice was mediated by the loss of GPR182 in hematopoietic cells or non-hematopoietic stromal cells, we performed a bone marrow (BM) chimera experiment where GPR182−/− and WT controls were lethally irradiated before reconstitution with BM cells from GPR182−/− or WT donor mice generating four different groups (Fig. 4a). Here, ACKR5 is linked to neoplasm.