Increased circulating proinflammatory cytokines and NFkB were reported in adolescent MDD and bipolar disorder, correlated with depressive symptoms severity60, and we have identified the proinflammatory NFkB pathway as a mediator of stress susceptibility in NAc endothelial cells of male8 but not female mice (Figs. 4 and 5). This evidence concerns the gene NFKB1 and bipolar disorder.