Quantities of granzyme B+, TNF+, and IFNg+ CD8+ cells were all significantly increased in PGRN Ab treatment when compared to the controls (Fig. 7i, S8e), which again, was significantly diminished with the anti-MHCI neutralizing Ab, confirming the indispensable role of MHCI in the PGRN Ab-induced tumor-specific cytotoxic effect. The gene discussed is TNF; the disease is neoplasm.