Here, with intracellular infection and with proteasome blockade treatment, we also found that pals-5p::GFP reporter expression was much lower or absent in zip-1(jy14) mutants than in wild-type animals, and indistinguishable from the phenotype of zip-1(jy13) mutants (Supplementary Fig. 3). The gene discussed is SLC39A1; the disease is infection.