In general, these results indicate that circFOXM1, which originates from FOXM1 mRNA, sponges miR-432, which regulates the expression of Gα12, further influencing the RhoGEF/RhoA/ROCK/PI3K pathway to mediate glioma-cell growth and aggressiveness (Fig. 7E). Here, RHOA is linked to central nervous system cancer.