One possibility for the different distribution patterns between ERG+ and ERG− tumor cells is that ERG+ tumor cells for each patient represented a distinctive cell state driven by a shared dominant oncogenic alteration, the TMPRSS2-ERG fusion event, though no such distinction was seen in ERG− tumor cells, suggesting more overlapping cell states between ERG− tumor cells and adjacent non-malignant LE cells. The gene discussed is TMPRSS2; the disease is neoplasm.