Compared to BE cells in PCa tissue samples, significantly higher percentages of BE cells in organoids expressed KRT6A (organoid vs tissue, 77.4% vs 0.56%, P < 2.2e-16, two-sided FET), KRT14 (organoid vs tissue, 71.2% vs 18.6%, P < 2.2e-16, two-sided FET) and KRT23 (organoid vs tissue, 78.8% vs 20.2%, P < 0.001, two-sided FET) (Supplementary Fig. 9e). This evidence concerns the gene KRT6A and posterior cortical atrophy.