CD4 and neoplasm: CD4 T-cell cluster 2 was enriched in ERG- patients with a 5.6 fold difference (9.5% vs 1.7%) (Fig. 7b) (P < 2.2e-16, two-sided FET) and was marked by higher expression of CXCR6 (log2FC = 1.31, FDR q = 1.5e-22), which was previously shown to be expressed in the type-1 polarized T-cell subset and to contribute to tumor progression51, and DUSP4 (log2FC = 1.30, FDR q = 1.4e-20).