TMPRSS2 and neoplasm: TMPRSS2-ERG fusion status was significantly positively correlated with an ERG + tumor cell signature score in both datasets (TCGA: information coefficient (IC) = 0.673, FDR q < 1e-5; SU2C: IC = 0.407, FDR q < 1e-5) and the absence of TMPRSS2-ERG fusion was significantly correlated with ERG- tumor signature scores (TCGA: IC = −0.554, FDR q < 1e-5; SU2C: IC = −0.211, FDR q < 1e-5) (Fig. 6f).