In both bulk RNA-seq datasets, AR signature scores were positively correlated with BE cluster 6 (IC = 0.756, FDR q < 1e-5) and Club cell cluster 0 (IC = 0.233, FDR q < 1e-5) (Fig. 5e), supporting our identification of cell states within BE cells and club cells that were more androgen-responsive and associated with prostate cancer. This evidence concerns the gene AR and Familial prostate cancer.