Using the DEGs between ERG+ and ERG− tumor cells (Supplementary Fig. 6d), we generated signature gene sets for both types of tumor cells and tested if the signatures of ERG+ and ERG− tumor cells generated from this dataset were correlated with TMPRSS2-ERG fusion status in TCGA25 and SU2C49 castration-resistant prostate cancer (CRPC) bulk RNA-seq datasets. The gene discussed is ERG; the disease is neoplasm.