SIRT1 and hepatocellular carcinoma: Moreover, we conducted luciferase reporter assays using vectors containing the 3′-UTR segments of AKT2 and SITR1 including the wild-type (WT) or the mutant miR-124-3p binding sites to verify the interaction between miR-124-3p.1 and AKT2/SIRT1 in HCC.