In vitro experiments have verified that NRMT inhibits chemosensitivity of retinoblastoma cells through the CENPA/Myc/Bcl2 axis, and in vivo experiments were designed to verify whether NRMT could inhibit chemosensitivity of retinoblastoma tissues through the CENPA/Myc/Bcl2 axis to promote tumorigenesis. The gene discussed is NTMT1; the disease is retinoblastoma.