In addition, RACGAP1 can also inactivate RAC1 by its GAP activity to play a tumor suppressor role, but the comprehensive effect of the two forces is to drive cancer development, indicating that upon EGF induction, SHCBP1 promotes cell motility through inhibition of the tumor suppressor effect of RACGAP1 in bladder cancer. The gene discussed is EGF; the disease is urinary bladder cancer.