We found that TGFβ-1, L1-70, and MIF were increased in the serum of old AD mice at 3 days after parabiosis surgery, and knock down of TGFβ-1 with siRNA in neuroblastoma cells decreased L1-70 and MIF expression along with the decrease in TGFβ-1. Here, TGFB1 is linked to neuroblastoma.