On the other hand, senescent cells can secrete a plethora of cytokines and growth factors including interleukin-6 (IL-6) and IL-8, termed as senescence-associated secretory phenotype (SASP), whereby establish an immunosuppressive, inflammatory and catabolic microenvironment to promote tumor growth and resistance to chemotherapy [12–15]. This evidence concerns the gene IL6 and neoplasm.