By analyzing NK1R mRNA expression and EGFR signaling from published NSCLC patient profiles (GSE130779 and GSE2514) [38, 39], we found that high NK1R expression was associated with EGFR signaling activity (Fig. 5A), implying that NK1R upregulation may be associated with enhanced EGFR function in NSCLC. Here, EGFR is linked to non-small cell lung carcinoma.