TACR1 and non-small cell lung carcinoma: By analyzing NK1R mRNA expression and EGFR signaling from published NSCLC patient profiles (GSE130779 and GSE2514) [38, 39], we found that high NK1R expression was associated with EGFR signaling activity (Fig. 5A), implying that NK1R upregulation may be associated with enhanced EGFR function in NSCLC.