We further analyzed NK1R expression in NSCLC and adjacent non-tumor tissues in two datasets GSE130779 and GSE2514 downloaded from GEO databases [38, 39], revealing that expression of NK1R was significantly upregulated in NSCLC tumor tissues compared with the adjacent non-tumor tissues or normal tissues (Fig. 1C). The gene discussed is TACR1; the disease is non-small cell lung carcinoma.