In this context, we asserted a hypothesis that TEVs-packaged miR-142-5p might control radioresistance in NPC via the HGF/c-Met and EGF/EGFR pathways, and subsequently set out to perform a series of experiments to verify this hypothesis, hoping to lend crucial support of further understanding in promising targets for NPC treatment. Here, HGF is linked to nasopharyngeal carcinoma.