Moreover, enhanced METTL14 inhibited pyroptosis level in myocardial tissues, including downregulation of NLRP3, caspase-1, and GSDMD-N (Fig. 4E), suggesting that METTL14-mediated m6A modification may suppress DCM through modulating pyroptosis. Here, METTL14 is linked to familial dilated cardiomyopathy.