Consistent with our findings, recent studies reported that the dysregulated Nlrp3 inflammasome activation is linked to the pathogenesis of other chronic diseases, including neurodegenerative diseases and degenerative osteoarthritis.29,30 Furthermore, results from several studies suggest that targeting Nlrp3 inflammasome has a therapeutic effect on IVDD.25,31 Results from Tang et al.32 demonstrated that honokiol could alleviate oxidative stress-induced ECM degradation and NP cell apoptosis by inhibiting thioredoxin interacting protein/Nlrp3/Casp1/IL-1β signaling axis. Here, TXNIP is linked to neurodegenerative disease.